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Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis

Gene methylation is an epigenetic alteration in hepatocellular carcinoma (HCC), and hepatitis B virus (HBV) plays a crucial role in carcinogenesis of HCC. However, the association between gene methylation and HBV infection in HCC remains unclear. In our study, we conducted a comprehensive meta-analy...

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Autores principales: Zhang, Cheng, Huang, Changxin, Sui, Xinbing, Zhong, Xueqing, Yang, Wenjun, Hu, Xiangrong, Li, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856736/
https://www.ncbi.nlm.nih.gov/pubmed/31772678
http://dx.doi.org/10.7150/jca.33005
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author Zhang, Cheng
Huang, Changxin
Sui, Xinbing
Zhong, Xueqing
Yang, Wenjun
Hu, Xiangrong
Li, Yongqiang
author_facet Zhang, Cheng
Huang, Changxin
Sui, Xinbing
Zhong, Xueqing
Yang, Wenjun
Hu, Xiangrong
Li, Yongqiang
author_sort Zhang, Cheng
collection PubMed
description Gene methylation is an epigenetic alteration in hepatocellular carcinoma (HCC), and hepatitis B virus (HBV) plays a crucial role in carcinogenesis of HCC. However, the association between gene methylation and HBV infection in HCC remains unclear. In our study, we conducted a comprehensive meta-analysis to evaluate the association. A total of 1,148 studies were initially retrieved from some literature database. After a four-step filtration, we obtained 69 case-control studies in this meta-analysis. Our results showed six genes (p16, RASSF1A, GSTP1, APC, p15 and SFRP1) in HBV-positive carcinoma tissues, one gene (GSTP1) in HBV-positive adjacent tissues and two gene (p16 and APC) in HBV-positive carcinoma serums, which were significantly hypermethylated. Subgroup meta-analysis by geographical populations revealed that GSTP1 methylation was significantly higher in HBV-positive carcinoma tissues in China and Japan. In addition, p16 and RASSF1A methylation was significantly higher in China but not in Japan. Our study indicated that HBV infection could induce DNA methylation in HCC and DNA methylation could lead to the development of HBV-related HCC.
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spelling pubmed-68567362019-11-26 Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis Zhang, Cheng Huang, Changxin Sui, Xinbing Zhong, Xueqing Yang, Wenjun Hu, Xiangrong Li, Yongqiang J Cancer Research Paper Gene methylation is an epigenetic alteration in hepatocellular carcinoma (HCC), and hepatitis B virus (HBV) plays a crucial role in carcinogenesis of HCC. However, the association between gene methylation and HBV infection in HCC remains unclear. In our study, we conducted a comprehensive meta-analysis to evaluate the association. A total of 1,148 studies were initially retrieved from some literature database. After a four-step filtration, we obtained 69 case-control studies in this meta-analysis. Our results showed six genes (p16, RASSF1A, GSTP1, APC, p15 and SFRP1) in HBV-positive carcinoma tissues, one gene (GSTP1) in HBV-positive adjacent tissues and two gene (p16 and APC) in HBV-positive carcinoma serums, which were significantly hypermethylated. Subgroup meta-analysis by geographical populations revealed that GSTP1 methylation was significantly higher in HBV-positive carcinoma tissues in China and Japan. In addition, p16 and RASSF1A methylation was significantly higher in China but not in Japan. Our study indicated that HBV infection could induce DNA methylation in HCC and DNA methylation could lead to the development of HBV-related HCC. Ivyspring International Publisher 2019-10-20 /pmc/articles/PMC6856736/ /pubmed/31772678 http://dx.doi.org/10.7150/jca.33005 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhang, Cheng
Huang, Changxin
Sui, Xinbing
Zhong, Xueqing
Yang, Wenjun
Hu, Xiangrong
Li, Yongqiang
Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
title Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
title_full Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
title_fullStr Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
title_full_unstemmed Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
title_short Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
title_sort association between gene methylation and hbv infection in hepatocellular carcinoma: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856736/
https://www.ncbi.nlm.nih.gov/pubmed/31772678
http://dx.doi.org/10.7150/jca.33005
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