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Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway

Liensinine, an isoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera Gaertn, has been shown to exhibit various phrenological effects, including anti‑cancer activity. The aim of this study is to investigate the effects and mechanisms of liensinine in human gastric cancer cells. In...

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Autores principales: Yang, Jia-hua, Yu, Kun, Si, Xian-ke, Li, Sen, Cao, Yi-jun, Li, Wei, Zhang, Ji-xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856755/
https://www.ncbi.nlm.nih.gov/pubmed/31772676
http://dx.doi.org/10.7150/jca.32691
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author Yang, Jia-hua
Yu, Kun
Si, Xian-ke
Li, Sen
Cao, Yi-jun
Li, Wei
Zhang, Ji-xun
author_facet Yang, Jia-hua
Yu, Kun
Si, Xian-ke
Li, Sen
Cao, Yi-jun
Li, Wei
Zhang, Ji-xun
author_sort Yang, Jia-hua
collection PubMed
description Liensinine, an isoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera Gaertn, has been shown to exhibit various phrenological effects, including anti‑cancer activity. The aim of this study is to investigate the effects and mechanisms of liensinine in human gastric cancer cells. In this study, we found liensinine can significantly inhibit gastric cancer cell proliferation in vitro and in vivo. Liensinine inducedgastric cancer cell apoptosis by increasing cleaved PARP, caspased 3 and caspased 9. Moreover, liensinine induced cycle arrest by downregulatingcyclinD1/cyclin‑dependent kinase4 and phosphorylated protein kinase B. Furthermore, we found liensinine increases ROS levels and inhibits the PI3K/AKT pathway. These data suggested that liensinine might represent a novel and effective agent against gastric cancer.
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spelling pubmed-68567552019-11-26 Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway Yang, Jia-hua Yu, Kun Si, Xian-ke Li, Sen Cao, Yi-jun Li, Wei Zhang, Ji-xun J Cancer Research Paper Liensinine, an isoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera Gaertn, has been shown to exhibit various phrenological effects, including anti‑cancer activity. The aim of this study is to investigate the effects and mechanisms of liensinine in human gastric cancer cells. In this study, we found liensinine can significantly inhibit gastric cancer cell proliferation in vitro and in vivo. Liensinine inducedgastric cancer cell apoptosis by increasing cleaved PARP, caspased 3 and caspased 9. Moreover, liensinine induced cycle arrest by downregulatingcyclinD1/cyclin‑dependent kinase4 and phosphorylated protein kinase B. Furthermore, we found liensinine increases ROS levels and inhibits the PI3K/AKT pathway. These data suggested that liensinine might represent a novel and effective agent against gastric cancer. Ivyspring International Publisher 2019-10-19 /pmc/articles/PMC6856755/ /pubmed/31772676 http://dx.doi.org/10.7150/jca.32691 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Yang, Jia-hua
Yu, Kun
Si, Xian-ke
Li, Sen
Cao, Yi-jun
Li, Wei
Zhang, Ji-xun
Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
title Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
title_full Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
title_fullStr Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
title_full_unstemmed Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
title_short Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
title_sort liensinine inhibited gastric cancer cell growth through ros generation and the pi3k/akt pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856755/
https://www.ncbi.nlm.nih.gov/pubmed/31772676
http://dx.doi.org/10.7150/jca.32691
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