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Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856760/ https://www.ncbi.nlm.nih.gov/pubmed/31644901 http://dx.doi.org/10.1016/j.celrep.2019.09.041 |
| _version_ | 1783470638728478720 |
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| author | Sande-Melón, Marcos Marques, Inês J. Galardi-Castilla, María Langa, Xavier Pérez-López, María Botos, Marius-Alexandru Sánchez-Iranzo, Héctor Guzmán-Martínez, Gabriela Ferreira Francisco, David Miguel Pavlinic, Dinko Benes, Vladimir Bruggmann, Rémy Mercader, Nadia |
| author_facet | Sande-Melón, Marcos Marques, Inês J. Galardi-Castilla, María Langa, Xavier Pérez-López, María Botos, Marius-Alexandru Sánchez-Iranzo, Héctor Guzmán-Martínez, Gabriela Ferreira Francisco, David Miguel Pavlinic, Dinko Benes, Vladimir Bruggmann, Rémy Mercader, Nadia |
| author_sort | Sande-Melón, Marcos |
| collection | PubMed |
| description | During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10(+) cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration. |
| format | Online Article Text |
| id | pubmed-6856760 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Cell Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68567602019-11-21 Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish Sande-Melón, Marcos Marques, Inês J. Galardi-Castilla, María Langa, Xavier Pérez-López, María Botos, Marius-Alexandru Sánchez-Iranzo, Héctor Guzmán-Martínez, Gabriela Ferreira Francisco, David Miguel Pavlinic, Dinko Benes, Vladimir Bruggmann, Rémy Mercader, Nadia Cell Rep Article During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10(+) cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration. Cell Press 2019-10-22 /pmc/articles/PMC6856760/ /pubmed/31644901 http://dx.doi.org/10.1016/j.celrep.2019.09.041 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Sande-Melón, Marcos Marques, Inês J. Galardi-Castilla, María Langa, Xavier Pérez-López, María Botos, Marius-Alexandru Sánchez-Iranzo, Héctor Guzmán-Martínez, Gabriela Ferreira Francisco, David Miguel Pavlinic, Dinko Benes, Vladimir Bruggmann, Rémy Mercader, Nadia Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish |
| title | Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish |
| title_full | Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish |
| title_fullStr | Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish |
| title_full_unstemmed | Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish |
| title_short | Adult sox10(+) Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish |
| title_sort | adult sox10(+) cardiomyocytes contribute to myocardial regeneration in the zebrafish |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856760/ https://www.ncbi.nlm.nih.gov/pubmed/31644901 http://dx.doi.org/10.1016/j.celrep.2019.09.041 |
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