Transition‐Metal‐Free Reductive Hydroxymethylation of Isoquinolines

A transition‐metal‐free reductive hydroxymethylation reaction has been developed, enabling the preparation of tetrahydroisoquinolines bearing C4‐quaternary centers from the corresponding isoquinolines. Deuterium labelling studies and control experiments enable a potential mechanism to be elucidated...

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Detalles Bibliográficos
Autores principales: Reeves, Benjamin M., Hepburn, Hamish B., Grozavu, Alexandru, Lindsay‐Scott, Peter J., Donohoe, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856840/
https://www.ncbi.nlm.nih.gov/pubmed/31486205
http://dx.doi.org/10.1002/anie.201908857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856840/
https://www.ncbi.nlm.nih.gov/pubmed/31486205
http://dx.doi.org/10.1002/anie.201908857

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