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Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study

Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs popula...

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Autores principales: Liu, Xiaosun, Yu, Hang, Yan, Chongxian, Mei, Ying, Lin, Caizhao, Hong, Yanyun, Lin, Xianke, Zhang, Qing, Yu, Jiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856898/
https://www.ncbi.nlm.nih.gov/pubmed/31777600
http://dx.doi.org/10.7150/jca.34826
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author Liu, Xiaosun
Yu, Hang
Yan, Chongxian
Mei, Ying
Lin, Caizhao
Hong, Yanyun
Lin, Xianke
Zhang, Qing
Yu, Jiren
author_facet Liu, Xiaosun
Yu, Hang
Yan, Chongxian
Mei, Ying
Lin, Caizhao
Hong, Yanyun
Lin, Xianke
Zhang, Qing
Yu, Jiren
author_sort Liu, Xiaosun
collection PubMed
description Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs population and its expression of inducible costimulator (ICOS) were analyzed in peripheral blood from 41 GC patients by multicolor flow cytometry. These cell populations in carcinoma tissue, peritumor tissue and normal gastric mucosa from 87 GC patients were also detected by immunohistochemistry and double immunofluorescence. Results: Both ICOS(+)Foxp3(+)Treg cells (P=0.0341 and P=0.0298, respectively) and pDC (P=0.0237 and P=0.0083, respectively) in peripheral blood and tumor tissue could predict poor clinical outcome in GC patients. However, the total Foxp3(+)Tregs in the GC tissue didn't correlated with the outcome (P=0.4299). No correlation of CD4(+) T cell or CD8(+) T cell frequency could be found with clinical outcome neither in peripheral blood nor in tumor tissue. Conclusions: ICOS(+)Tregs and pDCs could predict poor prognosis of GC, targeting ICOS-L/ICOS costimulation axis may be a potential treatment for GC.
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spelling pubmed-68568982019-11-27 Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study Liu, Xiaosun Yu, Hang Yan, Chongxian Mei, Ying Lin, Caizhao Hong, Yanyun Lin, Xianke Zhang, Qing Yu, Jiren J Cancer Research Paper Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs population and its expression of inducible costimulator (ICOS) were analyzed in peripheral blood from 41 GC patients by multicolor flow cytometry. These cell populations in carcinoma tissue, peritumor tissue and normal gastric mucosa from 87 GC patients were also detected by immunohistochemistry and double immunofluorescence. Results: Both ICOS(+)Foxp3(+)Treg cells (P=0.0341 and P=0.0298, respectively) and pDC (P=0.0237 and P=0.0083, respectively) in peripheral blood and tumor tissue could predict poor clinical outcome in GC patients. However, the total Foxp3(+)Tregs in the GC tissue didn't correlated with the outcome (P=0.4299). No correlation of CD4(+) T cell or CD8(+) T cell frequency could be found with clinical outcome neither in peripheral blood nor in tumor tissue. Conclusions: ICOS(+)Tregs and pDCs could predict poor prognosis of GC, targeting ICOS-L/ICOS costimulation axis may be a potential treatment for GC. Ivyspring International Publisher 2019-10-22 /pmc/articles/PMC6856898/ /pubmed/31777600 http://dx.doi.org/10.7150/jca.34826 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Liu, Xiaosun
Yu, Hang
Yan, Chongxian
Mei, Ying
Lin, Caizhao
Hong, Yanyun
Lin, Xianke
Zhang, Qing
Yu, Jiren
Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study
title Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study
title_full Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study
title_fullStr Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study
title_full_unstemmed Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study
title_short Plasmacytoid Dendritic Cells and ICOS(+) Regulatory T Cells Predict Poor Prognosis in Gastric Cancer: A Pilot Study
title_sort plasmacytoid dendritic cells and icos(+) regulatory t cells predict poor prognosis in gastric cancer: a pilot study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856898/
https://www.ncbi.nlm.nih.gov/pubmed/31777600
http://dx.doi.org/10.7150/jca.34826
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