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Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization
BACKGROUND: We have previously reported that histamine-induced pruritus was attenuated in toll-like receptor 4 (TLR4) knockout mice due to decreased transient receptor potential V1 (TRPV1) sensitivity. Our results implied that TLR4 potentiated TRPV1 activation in sensory neurons; however, the molecu...
Autores principales: | Min, Hyunjung, Cho, Woo-Hyun, Lee, Hyunkyoung, Choi, Boomin, Kim, Yoon-Jung, Lee, Han Kyu, Joo, Yeonhee, Jung, Sung Jun, Choi, Se-Young, Lee, Soojin, Lee, Sung Joong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856976/ https://www.ncbi.nlm.nih.gov/pubmed/30355052 http://dx.doi.org/10.1177/1744806918812636 |
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