Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease

Gene therapy can be designed to efficiently counter pathological features characteristic of neurodegenerative disorders. Here, we took advantage of the glial fibrillary acidic protein (GFAP) promoter to preferentially enhance transgene expression near plaques composed of amyloid-beta peptides (Aβ),...

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Detalles Bibliográficos
Autores principales: Weber-Adrian, Danielle, Kofoed, Rikke Hahn, Chan, Josephine Wing Yee, Silburt, Joseph, Noroozian, Zeinab, Kügler, Sebastian, Hynynen, Kullervo, Aubert, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857057/
https://www.ncbi.nlm.nih.gov/pubmed/31754385
http://dx.doi.org/10.7150/thno.36718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857057/
https://www.ncbi.nlm.nih.gov/pubmed/31754385
http://dx.doi.org/10.7150/thno.36718

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