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Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis

INTRODUCTION: Although chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) predominantly affects large myelinated fibers, many patients have pain. The aim of this paper is to systematically review the current literature regarding CIDP with a particular focus on epidemiological and clini...

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Autores principales: Michaelides, Athena, Hadden, Robert D. M., Sarrigiannis, Ptolemaios G., Hadjivassiliou, Marios, Zis, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857093/
https://www.ncbi.nlm.nih.gov/pubmed/31201680
http://dx.doi.org/10.1007/s40122-019-0128-y
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author Michaelides, Athena
Hadden, Robert D. M.
Sarrigiannis, Ptolemaios G.
Hadjivassiliou, Marios
Zis, Panagiotis
author_facet Michaelides, Athena
Hadden, Robert D. M.
Sarrigiannis, Ptolemaios G.
Hadjivassiliou, Marios
Zis, Panagiotis
author_sort Michaelides, Athena
collection PubMed
description INTRODUCTION: Although chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) predominantly affects large myelinated fibers, many patients have pain. The aim of this paper is to systematically review the current literature regarding CIDP with a particular focus on epidemiological and clinical characteristics of painful CIDP. METHODS: A systematic literature search was conducted on PubMed database. RESULTS: Our search strategy identified 146 articles. Thirty-eight papers, reporting on 991 patients, met the inclusion criteria and were used for this review. The pooled estimate of the prevalence of pain at any point within the course of CIDP was 46% (95% CI 36–57%). Immune treatment of CIDP might be adequate as monotherapy for the management of pain. Treatment specific to pain currently shows effectiveness as adjuvant treatment when CIDP is treated and pain persists. CONCLUSIONS: Pain in CIDP is an underexplored field. Future research should focus on the natural history, phenomenology, and management of pain in CIDP.
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spelling pubmed-68570932019-12-03 Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis Michaelides, Athena Hadden, Robert D. M. Sarrigiannis, Ptolemaios G. Hadjivassiliou, Marios Zis, Panagiotis Pain Ther Review INTRODUCTION: Although chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) predominantly affects large myelinated fibers, many patients have pain. The aim of this paper is to systematically review the current literature regarding CIDP with a particular focus on epidemiological and clinical characteristics of painful CIDP. METHODS: A systematic literature search was conducted on PubMed database. RESULTS: Our search strategy identified 146 articles. Thirty-eight papers, reporting on 991 patients, met the inclusion criteria and were used for this review. The pooled estimate of the prevalence of pain at any point within the course of CIDP was 46% (95% CI 36–57%). Immune treatment of CIDP might be adequate as monotherapy for the management of pain. Treatment specific to pain currently shows effectiveness as adjuvant treatment when CIDP is treated and pain persists. CONCLUSIONS: Pain in CIDP is an underexplored field. Future research should focus on the natural history, phenomenology, and management of pain in CIDP. Springer Healthcare 2019-06-14 2019-12 /pmc/articles/PMC6857093/ /pubmed/31201680 http://dx.doi.org/10.1007/s40122-019-0128-y Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Michaelides, Athena
Hadden, Robert D. M.
Sarrigiannis, Ptolemaios G.
Hadjivassiliou, Marios
Zis, Panagiotis
Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis
title Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis
title_full Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis
title_fullStr Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis
title_full_unstemmed Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis
title_short Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis
title_sort pain in chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857093/
https://www.ncbi.nlm.nih.gov/pubmed/31201680
http://dx.doi.org/10.1007/s40122-019-0128-y
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