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Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. According to the amyloid hypothesis, the accumulation and deposition of amyloid-beta (Aβ) peptides play a key role in AD. Soluble Aβ (sAβ) oligomers were shown to be involved in pathological hypersynchronisation of brain re...

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Detalles Bibliográficos
Autores principales:	Ben-Nejma, Inès R. H., Keliris, Aneta J., Daans, Jasmijn, Ponsaerts, Peter, Verhoye, Marleen, Van der Linden, Annemie, Keliris, Georgios A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857138/ https://www.ncbi.nlm.nih.gov/pubmed/31727182 http://dx.doi.org/10.1186/s40478-019-0810-7

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