The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies

BACKGROUND: The relationship between serum vitamin D and atrial fibrillation (AF) or postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass graft (CABG) is still debated. It is also unclear whether there is a dose-response relationship between circulating vitamin D an...

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Autores principales: Liu, Xiao, Wang, Wei, Tan, Zhaochong, Zhu, Xin, Liu, Menglu, Wan, Rong, Hong, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857145/
https://www.ncbi.nlm.nih.gov/pubmed/31727055
http://dx.doi.org/10.1186/s12937-019-0485-8
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author Liu, Xiao
Wang, Wei
Tan, Zhaochong
Zhu, Xin
Liu, Menglu
Wan, Rong
Hong, Kui
author_facet Liu, Xiao
Wang, Wei
Tan, Zhaochong
Zhu, Xin
Liu, Menglu
Wan, Rong
Hong, Kui
author_sort Liu, Xiao
collection PubMed
description BACKGROUND: The relationship between serum vitamin D and atrial fibrillation (AF) or postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass graft (CABG) is still debated. It is also unclear whether there is a dose-response relationship between circulating vitamin D and the risk of AF or POAF. METHODS: The Cochrane Library, PubMed, and Embase databases were searched for relevant studies. We used a “one-stage approach” with a restricted cubic spline model to summarize the dose-specific relationships between serum vitamin D and AF. Relative risk (RR) was used to measure the effects in this meta-analysis. RESULTS: In total, 13 studies were included with a total of 6519 cases of AF among 74,885 participants. Vitamin D deficiency (< 20 ng/ml) was associated with increased risks of AF (RR: 1.23, 95% CI: 1.05–1.43). In the dose-response analysis, the summary RR for a 10 ng/ml increased in vitamin D was 0.88 (95% CI: 0.78–0.98) and there was no evidence of a non-linear association, P(non-linearity) = 0.86. In the age subgroup, high vitamin D (per 10 ng/ml increase) reduced the risk of AF in the older group (> 65 years) (RR = 0.68, 95% CI = 0.52–0.89) but not among young individuals (< 65 years) (RR = 0.87, 95% CI = 0.72–1.06). In addition, a strong association was found between a 10 ng/ml increased in vitamin D and POAF incident in the patient after CABG (RR: 0.44, 95% CI: 0.24–0.82). CONCLUSION: Our dose-response meta-analysis suggested serum vitamin D deficiency was associated with an increased risk of AF in the general population and POAF in patients after CABG. Further studies are needed to explore the age difference in the association between serum vitamin D level and the risk of AF and whether vitamin D supplements will prevent AF. TRIAL REGISTRATION: This study has been registered with PROSPERO (International prospective register of systematic reviews)-registration number-CRD42019119258.
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spelling pubmed-68571452019-12-05 The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies Liu, Xiao Wang, Wei Tan, Zhaochong Zhu, Xin Liu, Menglu Wan, Rong Hong, Kui Nutr J Review BACKGROUND: The relationship between serum vitamin D and atrial fibrillation (AF) or postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass graft (CABG) is still debated. It is also unclear whether there is a dose-response relationship between circulating vitamin D and the risk of AF or POAF. METHODS: The Cochrane Library, PubMed, and Embase databases were searched for relevant studies. We used a “one-stage approach” with a restricted cubic spline model to summarize the dose-specific relationships between serum vitamin D and AF. Relative risk (RR) was used to measure the effects in this meta-analysis. RESULTS: In total, 13 studies were included with a total of 6519 cases of AF among 74,885 participants. Vitamin D deficiency (< 20 ng/ml) was associated with increased risks of AF (RR: 1.23, 95% CI: 1.05–1.43). In the dose-response analysis, the summary RR for a 10 ng/ml increased in vitamin D was 0.88 (95% CI: 0.78–0.98) and there was no evidence of a non-linear association, P(non-linearity) = 0.86. In the age subgroup, high vitamin D (per 10 ng/ml increase) reduced the risk of AF in the older group (> 65 years) (RR = 0.68, 95% CI = 0.52–0.89) but not among young individuals (< 65 years) (RR = 0.87, 95% CI = 0.72–1.06). In addition, a strong association was found between a 10 ng/ml increased in vitamin D and POAF incident in the patient after CABG (RR: 0.44, 95% CI: 0.24–0.82). CONCLUSION: Our dose-response meta-analysis suggested serum vitamin D deficiency was associated with an increased risk of AF in the general population and POAF in patients after CABG. Further studies are needed to explore the age difference in the association between serum vitamin D level and the risk of AF and whether vitamin D supplements will prevent AF. TRIAL REGISTRATION: This study has been registered with PROSPERO (International prospective register of systematic reviews)-registration number-CRD42019119258. BioMed Central 2019-11-14 /pmc/articles/PMC6857145/ /pubmed/31727055 http://dx.doi.org/10.1186/s12937-019-0485-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Liu, Xiao
Wang, Wei
Tan, Zhaochong
Zhu, Xin
Liu, Menglu
Wan, Rong
Hong, Kui
The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
title The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
title_full The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
title_fullStr The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
title_full_unstemmed The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
title_short The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies
title_sort relationship between vitamin d and risk of atrial fibrillation: a dose-response analysis of observational studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857145/
https://www.ncbi.nlm.nih.gov/pubmed/31727055
http://dx.doi.org/10.1186/s12937-019-0485-8
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