Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1

BACKGROUND: IRE1α-mediated unconventional splicing of XBP1 is emerging as a biomarker in several disease states and is indicative of activation of the unfolded protein response sensor IRE1. Splicing of XBP1 mRNA results in the translation of two distinct XBP1 protein isoforms (XBP1s and XBP1u) which...

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Detalles Bibliográficos
Autores principales: Creedican, Stuart, Talty, Aaron, Fitzgerald, Stephen P., Samali, Afshin, Richardson, Ciarán, Gorman, Adrienne M., Martin, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857227/
https://www.ncbi.nlm.nih.gov/pubmed/31807121
http://dx.doi.org/10.1186/s12575-019-0111-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857227/
https://www.ncbi.nlm.nih.gov/pubmed/31807121
http://dx.doi.org/10.1186/s12575-019-0111-3

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