Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

BACKGROUND: Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary arterioles leads to increased pulmonary pressures, right ventricular hypertrophy, and heart failure. Mutations in bone morphogenetic...

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Detalles Bibliográficos
Autores principales: Zhu, Na, Pauciulo, Michael W., Welch, Carrie L., Lutz, Katie A., Coleman, Anna W., Gonzaga-Jauregui, Claudia, Wang, Jiayao, Grimes, Joseph M., Martin, Lisa J., He, Hua, Shen, Yufeng, Chung, Wendy K., Nichols, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857288/
https://www.ncbi.nlm.nih.gov/pubmed/31727138
http://dx.doi.org/10.1186/s13073-019-0685-z

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