Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

BACKGROUND: Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes of the HR pathway or the DNA damage checkpoint also give r...

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Detalles Bibliográficos
Autores principales: Póti, Ádám, Gyergyák, Hella, Németh, Eszter, Rusz, Orsolya, Tóth, Szilárd, Kovácsházi, Csenger, Chen, Dan, Szikriszt, Bernadett, Spisák, Sándor, Takeda, Shunichi, Szakács, Gergely, Szallasi, Zoltan, Richardson, Andrea L., Szüts, Dávid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857305/
https://www.ncbi.nlm.nih.gov/pubmed/31727117
http://dx.doi.org/10.1186/s13059-019-1867-0

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