Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera

Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutatio...

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Detalles Bibliográficos
Autores principales: Singh, Akanksha, Mahto, Subodh Kumar, Prasad, Jyotsana, Sharma, Suman, Malhotra, Ashwani Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857364/
https://www.ncbi.nlm.nih.gov/pubmed/31742182
http://dx.doi.org/10.4103/jfmpc.jfmpc_628_19
Descripción
Sumario:Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutation and the molecular basis of JAK2V617F-negative PV is not known. We hereby report a case of a young man who presented with headache, vomiting and altered sensorium and was found to have recurrent CSVT. The patient had primary polycythemia and was subsequently diagnosed to have JAK2-negative PV.

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