Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera

Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutatio...

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Autores principales: Singh, Akanksha, Mahto, Subodh Kumar, Prasad, Jyotsana, Sharma, Suman, Malhotra, Ashwani Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857364/
https://www.ncbi.nlm.nih.gov/pubmed/31742182
http://dx.doi.org/10.4103/jfmpc.jfmpc_628_19
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author Singh, Akanksha
Mahto, Subodh Kumar
Prasad, Jyotsana
Sharma, Suman
Malhotra, Ashwani Kumar
author_facet Singh, Akanksha
Mahto, Subodh Kumar
Prasad, Jyotsana
Sharma, Suman
Malhotra, Ashwani Kumar
author_sort Singh, Akanksha
collection PubMed
description Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutation and the molecular basis of JAK2V617F-negative PV is not known. We hereby report a case of a young man who presented with headache, vomiting and altered sensorium and was found to have recurrent CSVT. The patient had primary polycythemia and was subsequently diagnosed to have JAK2-negative PV.
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spelling pubmed-68573642019-11-18 Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera Singh, Akanksha Mahto, Subodh Kumar Prasad, Jyotsana Sharma, Suman Malhotra, Ashwani Kumar J Family Med Prim Care Case Report Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutation and the molecular basis of JAK2V617F-negative PV is not known. We hereby report a case of a young man who presented with headache, vomiting and altered sensorium and was found to have recurrent CSVT. The patient had primary polycythemia and was subsequently diagnosed to have JAK2-negative PV. Wolters Kluwer - Medknow 2019-10-31 /pmc/articles/PMC6857364/ /pubmed/31742182 http://dx.doi.org/10.4103/jfmpc.jfmpc_628_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Singh, Akanksha
Mahto, Subodh Kumar
Prasad, Jyotsana
Sharma, Suman
Malhotra, Ashwani Kumar
Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
title Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
title_full Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
title_fullStr Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
title_full_unstemmed Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
title_short Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
title_sort recurrent cerebral venous sinus thrombosis in a young man- a case report of jak2-negative polycythemia vera
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857364/
https://www.ncbi.nlm.nih.gov/pubmed/31742182
http://dx.doi.org/10.4103/jfmpc.jfmpc_628_19
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