Association of leukemia and mitochondrial diseases—A review

Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in...

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Detalles Bibliográficos
Autores principales: Sachdeva, Ashwani, Rajguru, Jagadish Prasad, Sohi, Kanwardeep, Sachdeva, Swati Saggar, Kaur, Kirandeep, Devi, Rani, Rana, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857401/
https://www.ncbi.nlm.nih.gov/pubmed/31742129
http://dx.doi.org/10.4103/jfmpc.jfmpc_679_19
Descripción
Sumario:Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients.

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