Association of leukemia and mitochondrial diseases—A review

Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in...

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Autores principales: Sachdeva, Ashwani, Rajguru, Jagadish Prasad, Sohi, Kanwardeep, Sachdeva, Swati Saggar, Kaur, Kirandeep, Devi, Rani, Rana, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857401/
https://www.ncbi.nlm.nih.gov/pubmed/31742129
http://dx.doi.org/10.4103/jfmpc.jfmpc_679_19
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author Sachdeva, Ashwani
Rajguru, Jagadish Prasad
Sohi, Kanwardeep
Sachdeva, Swati Saggar
Kaur, Kirandeep
Devi, Rani
Rana, Vivek
author_facet Sachdeva, Ashwani
Rajguru, Jagadish Prasad
Sohi, Kanwardeep
Sachdeva, Swati Saggar
Kaur, Kirandeep
Devi, Rani
Rana, Vivek
author_sort Sachdeva, Ashwani
collection PubMed
description Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients.
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spelling pubmed-68574012019-11-18 Association of leukemia and mitochondrial diseases—A review Sachdeva, Ashwani Rajguru, Jagadish Prasad Sohi, Kanwardeep Sachdeva, Swati Saggar Kaur, Kirandeep Devi, Rani Rana, Vivek J Family Med Prim Care Review Article Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients. Wolters Kluwer - Medknow 2019-10-31 /pmc/articles/PMC6857401/ /pubmed/31742129 http://dx.doi.org/10.4103/jfmpc.jfmpc_679_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Sachdeva, Ashwani
Rajguru, Jagadish Prasad
Sohi, Kanwardeep
Sachdeva, Swati Saggar
Kaur, Kirandeep
Devi, Rani
Rana, Vivek
Association of leukemia and mitochondrial diseases—A review
title Association of leukemia and mitochondrial diseases—A review
title_full Association of leukemia and mitochondrial diseases—A review
title_fullStr Association of leukemia and mitochondrial diseases—A review
title_full_unstemmed Association of leukemia and mitochondrial diseases—A review
title_short Association of leukemia and mitochondrial diseases—A review
title_sort association of leukemia and mitochondrial diseases—a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857401/
https://www.ncbi.nlm.nih.gov/pubmed/31742129
http://dx.doi.org/10.4103/jfmpc.jfmpc_679_19
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