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Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review
Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857442/ https://www.ncbi.nlm.nih.gov/pubmed/31696865 http://dx.doi.org/10.12659/MSM.916719 |
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author | Guo, Wenjia Zhou, Qi Jia, Yanan Xu, Jiancheng |
author_facet | Guo, Wenjia Zhou, Qi Jia, Yanan Xu, Jiancheng |
author_sort | Guo, Wenjia |
collection | PubMed |
description | Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affect the results of diagnostic investigations, leading to false results. Red blood cell turnover in the bone marrow and the quality and heterogeneity of erythrocytes may influence the rate of hemoglobin glycation. By changing the structure of hemoglobin and inducing peroxidation, iron deficiency accelerates glycation. This review aims to discuss the possible causes of the association between increased levels of HbA1c and IDA. |
format | Online Article Text |
id | pubmed-6857442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68574422019-11-19 Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review Guo, Wenjia Zhou, Qi Jia, Yanan Xu, Jiancheng Med Sci Monit Review Articles Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affect the results of diagnostic investigations, leading to false results. Red blood cell turnover in the bone marrow and the quality and heterogeneity of erythrocytes may influence the rate of hemoglobin glycation. By changing the structure of hemoglobin and inducing peroxidation, iron deficiency accelerates glycation. This review aims to discuss the possible causes of the association between increased levels of HbA1c and IDA. International Scientific Literature, Inc. 2019-11-07 /pmc/articles/PMC6857442/ /pubmed/31696865 http://dx.doi.org/10.12659/MSM.916719 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Review Articles Guo, Wenjia Zhou, Qi Jia, Yanan Xu, Jiancheng Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review |
title | Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review |
title_full | Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review |
title_fullStr | Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review |
title_full_unstemmed | Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review |
title_short | Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review |
title_sort | increased levels of glycated hemoglobin a1c and iron deficiency anemia: a review |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857442/ https://www.ncbi.nlm.nih.gov/pubmed/31696865 http://dx.doi.org/10.12659/MSM.916719 |
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