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Reciprocal interactions between mtDNA and lifespan control in budding yeast
Loss of mitochondrial DNA (mtDNA) results in loss of mitochondrial respiratory activity, checkpoint-regulated inhibition of cell cycle progression, defects in growth, and nuclear genome instability. However, after several generations, yeast cells can adapt to the loss of mtDNA. During this adaptatio...
Autores principales: | Garcia, Enrique J., de Jonge, Janeska J., Liao, Pin-Chao, Stivison, Elizabeth, Sing, Cierra N., Higuchi-Sanabria, Ryo, Boldogh, Istvan R., Pon, Liza A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857569/ https://www.ncbi.nlm.nih.gov/pubmed/31599702 http://dx.doi.org/10.1091/mbc.E18-06-0356 |
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