GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126

Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GAT...

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Detalles Bibliográficos
Autores principales: Mahamud, Md. Riaj, Geng, Xin, Ho, Yen-Chun, Cha, Boksik, Kim, Yuenhee, Ma, Jing, Chen, Lijuan, Myers, Greggory, Camper, Sally, Mustacich, Debbie, Witte, Marlys, Choi, Dongwon, Hong, Young-Kwon, Chen, Hong, Varshney, Gaurav, Engel, James Douglas, Wang, Shusheng, Kim, Tae-Hoon, Lim, Kim-Chew, Srinivasan, R. Sathish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857586/
https://www.ncbi.nlm.nih.gov/pubmed/31582413
http://dx.doi.org/10.1242/dev.184218

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