A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates

When designing prodrugs, choosing an appropriate linker is the key to achieving efficient, controlled drug delivery. Herein, we report the use of a photocaged C4′-oxidized abasic site (PC4AP) as a light-responsive, self-immolative linker. Any amine- or hydroxyl-bearing drug can be loaded onto the li...

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Detalles Bibliográficos
Autores principales: Zang, Chuanlong, Wang, Huawei, Li, Tiantian, Zhang, Yingqian, Li, Jiahui, Shang, Mengdi, Du, Juanjuan, Xi, Zhen, Zhou, Chuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857671/
https://www.ncbi.nlm.nih.gov/pubmed/31762977
http://dx.doi.org/10.1039/c9sc03016f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857671/
https://www.ncbi.nlm.nih.gov/pubmed/31762977
http://dx.doi.org/10.1039/c9sc03016f

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