Appraising the causal relevance of DNA methylation for risk of lung cancer

BACKGROUND: DNA methylation changes in peripheral blood have recently been identified in relation to lung cancer risk. Some of these changes have been suggested to mediate part of the effect of smoking on lung cancer. However, limitations with conventional mediation analyses mean that the causal nat...

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Detalles Bibliográficos
Autores principales: Battram, Thomas, Richmond, Rebecca C, Baglietto, Laura, Haycock, Philip C, Perduca, Vittorio, Bojesen, Stig E, Gaunt, Tom R, Hemani, Gibran, Guida, Florence, Carreras-Torres, Robert, Hung, Rayjean, Amos, Christopher I, Freeman, Joshua R, Sandanger, Torkjel M, Nøst, Therese H, Nordestgaard, Børge G, Teschendorff, Andrew E, Polidoro, Silvia, Vineis, Paolo, Severi, Gianluca, Hodge, Allison M, Giles, Graham G, Grankvist, Kjell, Johansson, Mikael B, Johansson, Mattias, Davey Smith, George, Relton, Caroline L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Mendelian Randomization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857764/
https://www.ncbi.nlm.nih.gov/pubmed/31549173
http://dx.doi.org/10.1093/ije/dyz190

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