Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis

PURPOSE: The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis. METHODS: Inflammation-induced corneal neovascularization experiments were performed in Dp71-null mice and C57BL/6J wild-type mice. RESULTS: The corneal neovascular area covered by neovascularization was...

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Detalles Bibliográficos
Autores principales: Ortiz, Gabriella, Vacca, Ophélie, Bénard, Romain, Dupas, Bénédicte, Sennlaub, Florian, Guillonneau, Xavier, JA, Sahel, Tadayoni, Ramin, Rendon, Alvaro, Giocanti-Aurégan, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857772/
https://www.ncbi.nlm.nih.gov/pubmed/31814696
Descripción
Sumario:PURPOSE: The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis. METHODS: Inflammation-induced corneal neovascularization experiments were performed in Dp71-null mice and C57BL/6J wild-type mice. RESULTS: The corneal neovascular area covered by neovascularization was larger in the injured corneas of the Dp71-null mice compared to the corneas of the wild-type mice: 40.72% versus 26.33%, respectively (p<0.005). Moreover, increased angiogenesis was associated with a high expression of vascular endothelial growth factor (VEGF). Similarly, aortic ring assays showed a significant enhancement of the neovascular area. CONCLUSIONS: These results suggest that dystrophin Dp71 could play an important role as a negative regulator of corneal angiogenesis.

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