Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis

PURPOSE: The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis. METHODS: Inflammation-induced corneal neovascularization experiments were performed in Dp71-null mice and C57BL/6J wild-type mice. RESULTS: The corneal neovascular area covered by neovascularization was...

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Autores principales: Ortiz, Gabriella, Vacca, Ophélie, Bénard, Romain, Dupas, Bénédicte, Sennlaub, Florian, Guillonneau, Xavier, JA, Sahel, Tadayoni, Ramin, Rendon, Alvaro, Giocanti-Aurégan, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857772/
https://www.ncbi.nlm.nih.gov/pubmed/31814696
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author Ortiz, Gabriella
Vacca, Ophélie
Bénard, Romain
Dupas, Bénédicte
Sennlaub, Florian
Guillonneau, Xavier
JA, Sahel
Tadayoni, Ramin
Rendon, Alvaro
Giocanti-Aurégan, Audrey
author_facet Ortiz, Gabriella
Vacca, Ophélie
Bénard, Romain
Dupas, Bénédicte
Sennlaub, Florian
Guillonneau, Xavier
JA, Sahel
Tadayoni, Ramin
Rendon, Alvaro
Giocanti-Aurégan, Audrey
author_sort Ortiz, Gabriella
collection PubMed
description PURPOSE: The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis. METHODS: Inflammation-induced corneal neovascularization experiments were performed in Dp71-null mice and C57BL/6J wild-type mice. RESULTS: The corneal neovascular area covered by neovascularization was larger in the injured corneas of the Dp71-null mice compared to the corneas of the wild-type mice: 40.72% versus 26.33%, respectively (p<0.005). Moreover, increased angiogenesis was associated with a high expression of vascular endothelial growth factor (VEGF). Similarly, aortic ring assays showed a significant enhancement of the neovascular area. CONCLUSIONS: These results suggest that dystrophin Dp71 could play an important role as a negative regulator of corneal angiogenesis.
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spelling pubmed-68577722019-12-06 Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis Ortiz, Gabriella Vacca, Ophélie Bénard, Romain Dupas, Bénédicte Sennlaub, Florian Guillonneau, Xavier JA, Sahel Tadayoni, Ramin Rendon, Alvaro Giocanti-Aurégan, Audrey Mol Vis Research Article PURPOSE: The aim of this study was to define the role of dystrophin Dp71 in corneal angiogenesis. METHODS: Inflammation-induced corneal neovascularization experiments were performed in Dp71-null mice and C57BL/6J wild-type mice. RESULTS: The corneal neovascular area covered by neovascularization was larger in the injured corneas of the Dp71-null mice compared to the corneas of the wild-type mice: 40.72% versus 26.33%, respectively (p<0.005). Moreover, increased angiogenesis was associated with a high expression of vascular endothelial growth factor (VEGF). Similarly, aortic ring assays showed a significant enhancement of the neovascular area. CONCLUSIONS: These results suggest that dystrophin Dp71 could play an important role as a negative regulator of corneal angiogenesis. Molecular Vision 2019-11-14 /pmc/articles/PMC6857772/ /pubmed/31814696 Text en Copyright © 2019 Molecular Vision. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.
spellingShingle Research Article
Ortiz, Gabriella
Vacca, Ophélie
Bénard, Romain
Dupas, Bénédicte
Sennlaub, Florian
Guillonneau, Xavier
JA, Sahel
Tadayoni, Ramin
Rendon, Alvaro
Giocanti-Aurégan, Audrey
Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
title Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
title_full Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
title_fullStr Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
title_full_unstemmed Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
title_short Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
title_sort evidence of the involvement of dystrophin dp71 in corneal angiogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857772/
https://www.ncbi.nlm.nih.gov/pubmed/31814696
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