N-terminal sequences in Matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements

RNA binding proteins associated with amyotrophic lateral sclerosis (ALS) and muscle myopathy possess sequence elements that are low in complexity, or bear resemblance to yeast prion domains. These sequence elements appear to mediate phase separation into liquid-like membraneless organelles. Using fu...

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Detalles Bibliográficos
Autores principales: Gallego-Iradi, M. Carolina, Strunk, Haley, Crown, Anthony M., Davila, Rachel, Brown, Hilda, Rodriguez-Lebron, Edgardo, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857798/
https://www.ncbi.nlm.nih.gov/pubmed/31019288
http://dx.doi.org/10.1038/s41374-019-0260-7

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