O-GlcNAcylation of GLI Transcription Factors in Hyperglycemic Conditions Augments Hedgehog activity: Hyperglycemic conditions upregulate GLI activity

Modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) promotes tumor cell survival, proliferation, epigenetic changes, angiogenesis, invasion, and metastasis. Here we demonstrate that in conditions of elevated glucose, there is increased expression of key drug resistance proteins (AB...

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Detalles Bibliográficos
Autores principales: Das, Shamik, Bailey, Sarah K., Metge, Brandon J., Hanna, Ann, Hinshaw, Dominique C., Mota, Mateus, Forero-Torres, Andres, Chatham, John C., Samant, Rajeev S., Shevde, Lalita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857801/
https://www.ncbi.nlm.nih.gov/pubmed/30420690
http://dx.doi.org/10.1038/s41374-018-0122-8

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