Cargando…
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila
Although glucose-sensing neurons were discovered more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. Here, we identify a pair of glucose-sensing neurons (dubbed CN neurons) in the Drosophila brain with bifurcating axons whereby one axon branch projects to...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857815/ https://www.ncbi.nlm.nih.gov/pubmed/31645735 http://dx.doi.org/10.1038/s41586-019-1675-4 |
_version_ | 1783470827623153664 |
---|---|
author | Oh, Yangkyun Lai, Jason Sih-Yu Mills, Holly J. Erdjument-Bromage, Hediye Giammarinaro, Benno Saadipour, Khalil Wang, Justin G. Abu, Farhan Neubert, Thomas A. Suh, Greg S. B. |
author_facet | Oh, Yangkyun Lai, Jason Sih-Yu Mills, Holly J. Erdjument-Bromage, Hediye Giammarinaro, Benno Saadipour, Khalil Wang, Justin G. Abu, Farhan Neubert, Thomas A. Suh, Greg S. B. |
author_sort | Oh, Yangkyun |
collection | PubMed |
description | Although glucose-sensing neurons were discovered more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. Here, we identify a pair of glucose-sensing neurons (dubbed CN neurons) in the Drosophila brain with bifurcating axons whereby one axon branch projects to insulin-producing cells (IPCs) to trigger the release of Drosophila insulin-like peptide 2 (dilp2), and the other one extends to adipokinetic hormone (AKH)–producing cells to inhibit the secretion of AKH, fly’s analog of glucagon. These axonal branches undergo synaptic remodeling in response to changes in their internal energy status. Silencing of CN neurons largely disabled IPCs’ response to glucose and dilp2 secretion, and disinhibited AKH secretion in corpora cardiaca (CC), and caused hyperglycemia, a hallmark feature of diabetes mellitus. We propose that CN neurons maintain glucose homeostasis by promoting the secretion of dilp2 and suppressing the release of AKH when hemolymph glucose levels are high. |
format | Online Article Text |
id | pubmed-6857815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-68578152020-04-23 A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila Oh, Yangkyun Lai, Jason Sih-Yu Mills, Holly J. Erdjument-Bromage, Hediye Giammarinaro, Benno Saadipour, Khalil Wang, Justin G. Abu, Farhan Neubert, Thomas A. Suh, Greg S. B. Nature Article Although glucose-sensing neurons were discovered more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. Here, we identify a pair of glucose-sensing neurons (dubbed CN neurons) in the Drosophila brain with bifurcating axons whereby one axon branch projects to insulin-producing cells (IPCs) to trigger the release of Drosophila insulin-like peptide 2 (dilp2), and the other one extends to adipokinetic hormone (AKH)–producing cells to inhibit the secretion of AKH, fly’s analog of glucagon. These axonal branches undergo synaptic remodeling in response to changes in their internal energy status. Silencing of CN neurons largely disabled IPCs’ response to glucose and dilp2 secretion, and disinhibited AKH secretion in corpora cardiaca (CC), and caused hyperglycemia, a hallmark feature of diabetes mellitus. We propose that CN neurons maintain glucose homeostasis by promoting the secretion of dilp2 and suppressing the release of AKH when hemolymph glucose levels are high. 2019-10-23 2019-10 /pmc/articles/PMC6857815/ /pubmed/31645735 http://dx.doi.org/10.1038/s41586-019-1675-4 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Oh, Yangkyun Lai, Jason Sih-Yu Mills, Holly J. Erdjument-Bromage, Hediye Giammarinaro, Benno Saadipour, Khalil Wang, Justin G. Abu, Farhan Neubert, Thomas A. Suh, Greg S. B. A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
title | A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
title_full | A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
title_fullStr | A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
title_full_unstemmed | A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
title_short | A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
title_sort | glucose-sensing neuron pair regulates insulin and glucagon in drosophila |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857815/ https://www.ncbi.nlm.nih.gov/pubmed/31645735 http://dx.doi.org/10.1038/s41586-019-1675-4 |
work_keys_str_mv | AT ohyangkyun aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT laijasonsihyu aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT millshollyj aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT erdjumentbromagehediye aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT giammarinarobenno aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT saadipourkhalil aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT wangjusting aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT abufarhan aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT neubertthomasa aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT suhgregsb aglucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT ohyangkyun glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT laijasonsihyu glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT millshollyj glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT erdjumentbromagehediye glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT giammarinarobenno glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT saadipourkhalil glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT wangjusting glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT abufarhan glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT neubertthomasa glucosesensingneuronpairregulatesinsulinandglucagonindrosophila AT suhgregsb glucosesensingneuronpairregulatesinsulinandglucagonindrosophila |