Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges

Factor V (FV) deficiency (F5D) is a rare hematological disorder with a variable spectrum of bleeding manifestations. Until now, no specific protocols for the management of these patients have been established. However, available literature suggests that perioperative infusion of fresh frozen plasma...

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Detalles Bibliográficos
Autores principales: Bello, Alexa, Salazar, Eric, Heyne, Kirk, Varon, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Hematology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857824/
https://www.ncbi.nlm.nih.gov/pubmed/31788376
http://dx.doi.org/10.7759/cureus.5918
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author Bello, Alexa
Salazar, Eric
Heyne, Kirk
Varon, Joseph
author_facet Bello, Alexa
Salazar, Eric
Heyne, Kirk
Varon, Joseph
author_sort Bello, Alexa
collection PubMed
description Factor V (FV) deficiency (F5D) is a rare hematological disorder with a variable spectrum of bleeding manifestations. Until now, no specific protocols for the management of these patients have been established. However, available literature suggests that perioperative infusion of fresh frozen plasma (FFP) may help maintain FV levels to prevent bleeding. We present the case of a 64-year-old man with previously undiagnosed severe FV deficiency and mild FV inhibitor, who underwent aortic valve replacement with no bleeding complications.
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spelling pubmed-68578242019-11-30 Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges Bello, Alexa Salazar, Eric Heyne, Kirk Varon, Joseph Cureus Hematology Factor V (FV) deficiency (F5D) is a rare hematological disorder with a variable spectrum of bleeding manifestations. Until now, no specific protocols for the management of these patients have been established. However, available literature suggests that perioperative infusion of fresh frozen plasma (FFP) may help maintain FV levels to prevent bleeding. We present the case of a 64-year-old man with previously undiagnosed severe FV deficiency and mild FV inhibitor, who underwent aortic valve replacement with no bleeding complications. Cureus 2019-10-15 /pmc/articles/PMC6857824/ /pubmed/31788376 http://dx.doi.org/10.7759/cureus.5918 Text en Copyright © 2019, Bello et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Hematology
Bello, Alexa
Salazar, Eric
Heyne, Kirk
Varon, Joseph
Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges
title Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges
title_full Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges
title_fullStr Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges
title_full_unstemmed Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges
title_short Aortic Valve Replacement in Severe Factor V Deficiency and Inhibitor: Diagnostic and Management Challenges
title_sort aortic valve replacement in severe factor v deficiency and inhibitor: diagnostic and management challenges
topic Hematology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857824/
https://www.ncbi.nlm.nih.gov/pubmed/31788376
http://dx.doi.org/10.7759/cureus.5918
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