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Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma?
INTRODUCTION:: Neuroblastoma (NBL) is the most common extracranial solid tumor in children. It accounts for 15% of the deaths from cancer in the pediatric age group. Approximately half of the newly diagnosed children are at “high risk” (HR) of treatment failure. This study aim was to evaluate the im...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857875/ https://www.ncbi.nlm.nih.gov/pubmed/31128057 http://dx.doi.org/10.31557/APJCP.2019.20.5.1519 |
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author | Fawzy, Mohamed Hamoda, Asmaa Elhemaly, Ahmed Elkinaai, Naglaa Soliman, Sonya Reda, Hala Elmenawi, Salma Moussa, Emad |
author_facet | Fawzy, Mohamed Hamoda, Asmaa Elhemaly, Ahmed Elkinaai, Naglaa Soliman, Sonya Reda, Hala Elmenawi, Salma Moussa, Emad |
author_sort | Fawzy, Mohamed |
collection | PubMed |
description | INTRODUCTION:: Neuroblastoma (NBL) is the most common extracranial solid tumor in children. It accounts for 15% of the deaths from cancer in the pediatric age group. Approximately half of the newly diagnosed children are at “high risk” (HR) of treatment failure. This study aim was to evaluate the impact of salvage chemotherapy ICE (ifosfamide, carboplatin, and etoposide) versus TC (topotecan/cyclophosphamide) when administered to NBL HR patients having residual bone marrow disease after primary tumor control on the first line treatment regimen. MATERIALS AND METHODS: The present retrospective study included two groups of eligible stage 4 NBL patients with persistent bone marrow disease. Group (1), 29 patients, received ICE whereas less intensive TC was administered to Group (2), 32 patients. Data analysis included epidemiological variables, pathology subtype, MYCN gene status, primary tumor response and their correlation with bone marrow disease clearance on each regimen. RESULTS: A higher tendency of complete bone marrow clearance was reported in patients who received ICE compared to TC; 41.4% versus 25.0%, respectively. However, the difference was not statistically significant (p= 0.174). CONCLUSION: TC regimen appears to be a good alternative to ICE as salvage treatment in an attempt to clear NBL bone marrow residual, with the privilege of being less toxic and can be given on outpatient basis. Further randomized trials of larger study sample size with survival impact analysis are warranted. |
format | Online Article Text |
id | pubmed-6857875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-68578752019-12-12 Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? Fawzy, Mohamed Hamoda, Asmaa Elhemaly, Ahmed Elkinaai, Naglaa Soliman, Sonya Reda, Hala Elmenawi, Salma Moussa, Emad Asian Pac J Cancer Prev Research Article INTRODUCTION:: Neuroblastoma (NBL) is the most common extracranial solid tumor in children. It accounts for 15% of the deaths from cancer in the pediatric age group. Approximately half of the newly diagnosed children are at “high risk” (HR) of treatment failure. This study aim was to evaluate the impact of salvage chemotherapy ICE (ifosfamide, carboplatin, and etoposide) versus TC (topotecan/cyclophosphamide) when administered to NBL HR patients having residual bone marrow disease after primary tumor control on the first line treatment regimen. MATERIALS AND METHODS: The present retrospective study included two groups of eligible stage 4 NBL patients with persistent bone marrow disease. Group (1), 29 patients, received ICE whereas less intensive TC was administered to Group (2), 32 patients. Data analysis included epidemiological variables, pathology subtype, MYCN gene status, primary tumor response and their correlation with bone marrow disease clearance on each regimen. RESULTS: A higher tendency of complete bone marrow clearance was reported in patients who received ICE compared to TC; 41.4% versus 25.0%, respectively. However, the difference was not statistically significant (p= 0.174). CONCLUSION: TC regimen appears to be a good alternative to ICE as salvage treatment in an attempt to clear NBL bone marrow residual, with the privilege of being less toxic and can be given on outpatient basis. Further randomized trials of larger study sample size with survival impact analysis are warranted. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6857875/ /pubmed/31128057 http://dx.doi.org/10.31557/APJCP.2019.20.5.1519 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Fawzy, Mohamed Hamoda, Asmaa Elhemaly, Ahmed Elkinaai, Naglaa Soliman, Sonya Reda, Hala Elmenawi, Salma Moussa, Emad Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? |
title | Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? |
title_full | Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? |
title_fullStr | Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? |
title_full_unstemmed | Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? |
title_short | Does Salvage Chemotherapy Regimen Intensity Embark on Clearance of Bone Marrow Neuroblastoma? |
title_sort | does salvage chemotherapy regimen intensity embark on clearance of bone marrow neuroblastoma? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857875/ https://www.ncbi.nlm.nih.gov/pubmed/31128057 http://dx.doi.org/10.31557/APJCP.2019.20.5.1519 |
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