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Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative

OBJECTIVE: To determine if people with incident accelerated knee osteoarthritis (AKOA) were more likely to receive a pharmacological treatment or arthroscopic knee surgery than those with typical knee osteoarthritis (KOA) or no KOA. METHODS: We conducted a nested cohort study using data from baselin...

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Autores principales: Davis, Julie E., Harkey, Matthew S., Liu, Shao‐Hsien, Lapane, Kate, Price, Lori Lyn, Lu, Bing, Lo, Grace H., Eaton, Charles B., Barbe, Mary F., McAlindon, Timothy E., Driban, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857962/
https://www.ncbi.nlm.nih.gov/pubmed/31777814
http://dx.doi.org/10.1002/acr2.11058
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author Davis, Julie E.
Harkey, Matthew S.
Liu, Shao‐Hsien
Lapane, Kate
Price, Lori Lyn
Lu, Bing
Lo, Grace H.
Eaton, Charles B.
Barbe, Mary F.
McAlindon, Timothy E.
Driban, Jeffrey B.
author_facet Davis, Julie E.
Harkey, Matthew S.
Liu, Shao‐Hsien
Lapane, Kate
Price, Lori Lyn
Lu, Bing
Lo, Grace H.
Eaton, Charles B.
Barbe, Mary F.
McAlindon, Timothy E.
Driban, Jeffrey B.
author_sort Davis, Julie E.
collection PubMed
description OBJECTIVE: To determine if people with incident accelerated knee osteoarthritis (AKOA) were more likely to receive a pharmacological treatment or arthroscopic knee surgery than those with typical knee osteoarthritis (KOA) or no KOA. METHODS: We conducted a nested cohort study using data from baseline and the first 8 years of the Osteoarthritis Initiative. Eligible participants had no radiographic KOA at baseline (Kellgren‐Lawrence [KL] < 2). We classified three groups using KL grades: 1) AKOA: knee progressed to advanced‐stage KOA (KL 3/4) in 4 years or less, 2) typical KOA: knee increased in KL grade by 8 years (excluding AKOA), and 3) No KOA: no change in KL grade by 8 years. The outcome was self‐reported arthroscopic knee surgery or a pharmacological treatment option: nonsteroidal anti‐inflammatory drugs (NSAIDs), hyaluronic acid injections, intra‐articular corticosteroid injections, or prescription analgesics. Between‐group differences in therapeutic use were evaluated with Chi‐square tests. RESULTS: Adults who developed AKOA (n = 92) were more likely to report arthroscopic knee surgery (AKOA: 32%, KOA [n = 380]: 8%, no KOA [n = 875]: 3%; P < 0.001), hyaluronic acid injections (AKOA: 10%, KOA: 4%, no KOA: 1%; P < 0.001), intra‐articular corticosteroid injections (AKOA: 30%, KOA: 7%, no KOA: 4%; P < 0.001), and NSAID use (over the counter: AKOA: 65%, KOA: 48%, and no KOA: 46%; P = 0.003; prescription: AKOA: 61%, KOA: 43%, no KOA: 41%; P = 0.002). CONCLUSION: Adults with AKOA are more likely to receive pharmacological treatment or arthroscopic knee surgery than their peers. Adults with AKOA are an important patient population that is understudied in clinical research despite their use of greater health care resources.
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spelling pubmed-68579622019-11-27 Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative Davis, Julie E. Harkey, Matthew S. Liu, Shao‐Hsien Lapane, Kate Price, Lori Lyn Lu, Bing Lo, Grace H. Eaton, Charles B. Barbe, Mary F. McAlindon, Timothy E. Driban, Jeffrey B. ACR Open Rheumatol Brief Report OBJECTIVE: To determine if people with incident accelerated knee osteoarthritis (AKOA) were more likely to receive a pharmacological treatment or arthroscopic knee surgery than those with typical knee osteoarthritis (KOA) or no KOA. METHODS: We conducted a nested cohort study using data from baseline and the first 8 years of the Osteoarthritis Initiative. Eligible participants had no radiographic KOA at baseline (Kellgren‐Lawrence [KL] < 2). We classified three groups using KL grades: 1) AKOA: knee progressed to advanced‐stage KOA (KL 3/4) in 4 years or less, 2) typical KOA: knee increased in KL grade by 8 years (excluding AKOA), and 3) No KOA: no change in KL grade by 8 years. The outcome was self‐reported arthroscopic knee surgery or a pharmacological treatment option: nonsteroidal anti‐inflammatory drugs (NSAIDs), hyaluronic acid injections, intra‐articular corticosteroid injections, or prescription analgesics. Between‐group differences in therapeutic use were evaluated with Chi‐square tests. RESULTS: Adults who developed AKOA (n = 92) were more likely to report arthroscopic knee surgery (AKOA: 32%, KOA [n = 380]: 8%, no KOA [n = 875]: 3%; P < 0.001), hyaluronic acid injections (AKOA: 10%, KOA: 4%, no KOA: 1%; P < 0.001), intra‐articular corticosteroid injections (AKOA: 30%, KOA: 7%, no KOA: 4%; P < 0.001), and NSAID use (over the counter: AKOA: 65%, KOA: 48%, and no KOA: 46%; P = 0.003; prescription: AKOA: 61%, KOA: 43%, no KOA: 41%; P = 0.002). CONCLUSION: Adults with AKOA are more likely to receive pharmacological treatment or arthroscopic knee surgery than their peers. Adults with AKOA are an important patient population that is understudied in clinical research despite their use of greater health care resources. John Wiley and Sons Inc. 2019-07-25 /pmc/articles/PMC6857962/ /pubmed/31777814 http://dx.doi.org/10.1002/acr2.11058 Text en © 2019 The Authors. ACR Open Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Brief Report
Davis, Julie E.
Harkey, Matthew S.
Liu, Shao‐Hsien
Lapane, Kate
Price, Lori Lyn
Lu, Bing
Lo, Grace H.
Eaton, Charles B.
Barbe, Mary F.
McAlindon, Timothy E.
Driban, Jeffrey B.
Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative
title Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative
title_full Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative
title_fullStr Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative
title_full_unstemmed Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative
title_short Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative
title_sort adults with incident accelerated knee osteoarthritis are more likely to use pharmacological treatment options and receive arthroscopic knee surgery: data from the osteoarthritis initiative
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857962/
https://www.ncbi.nlm.nih.gov/pubmed/31777814
http://dx.doi.org/10.1002/acr2.11058
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