Association of SLCO1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients

OBJECTIVE: Variants in the SLCO1B1 gene, encoding a hepatic methotrexate (MTX) transporter, affect clearance of high‐dose MTX. We tested whether in the *14 and *15 alleles of SLCO1B1 influenced the response to low‐dose MTX in juvenile idiopathic arthritis (JIA) patients. METHODS: The study included...

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Detalles Bibliográficos
Autores principales: Ramsey, Laura B., Moncrieffe, Halima, Smith, Chelsey N., Sudman, Marc, Marion, Miranda C., Langefeld, Carl D., Becker, Mara L., Thompson, Susan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858017/
https://www.ncbi.nlm.nih.gov/pubmed/31777781
http://dx.doi.org/10.1002/acr2.1008

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