Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domai...

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Detalles Bibliográficos
Autores principales: Morgens, David W, Chan, Charlene, Kane, Andrew J, Weir, Nicholas R, Li, Amy, Dubreuil, Michael M, Tsui, C Kimberly, Hess, Gaelen T, Lavertu, Adam, Han, Kyuho, Polyakov, Nicole, Zhou, Jing, Handy, Emma L, Alabi, Philip, Dombroski, Amanda, Yao, David, Altman, Russ B, Sello, Jason K, Denic, Vladimir, Bassik, Michael C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858068/
https://www.ncbi.nlm.nih.gov/pubmed/31674906
http://dx.doi.org/10.7554/eLife.48434

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