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Determination of topographical radiation dose profiles using gel nanosensors

Despite the emergence of sophisticated technologies in treatment planning and administration, routine determination of delivered radiation doses remains a challenge due to limitations associated with conventional dosimeters. Here, we describe a gel-based nanosensor for the colorimetric detection and...

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Autores principales: Pushpavanam, Karthik, Inamdar, Sahil, Dutta, Subhadeep, Bista, Tomasz, Sokolowski, Thaddeus, Boshoven, Eric, Sapareto, Stephen, Rege, Kaushal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858262/
https://www.ncbi.nlm.nih.gov/pubmed/31763446
http://dx.doi.org/10.1126/sciadv.aaw8704
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author Pushpavanam, Karthik
Inamdar, Sahil
Dutta, Subhadeep
Bista, Tomasz
Sokolowski, Thaddeus
Boshoven, Eric
Sapareto, Stephen
Rege, Kaushal
author_facet Pushpavanam, Karthik
Inamdar, Sahil
Dutta, Subhadeep
Bista, Tomasz
Sokolowski, Thaddeus
Boshoven, Eric
Sapareto, Stephen
Rege, Kaushal
author_sort Pushpavanam, Karthik
collection PubMed
description Despite the emergence of sophisticated technologies in treatment planning and administration, routine determination of delivered radiation doses remains a challenge due to limitations associated with conventional dosimeters. Here, we describe a gel-based nanosensor for the colorimetric detection and quantification of topographical radiation dose profiles in radiotherapy. Exposure to ionizing radiation results in the conversion of gold ions in the gel to gold nanoparticles, which render a visual change in color in the gel due to their plasmonic properties. The intensity of color formed in the gel was used as a quantitative reporter of ionizing radiation. The gel nanosensor was used to detect complex topographical dose patterns including those administered to an anthropomorphic phantom and live canine patients undergoing clinical radiotherapy. The ease of fabrication, operation, rapid readout, colorimetric detection, and relatively low cost illustrate the translational potential of this technology for topographical dose mapping in radiotherapy applications in the clinic.
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spelling pubmed-68582622019-11-22 Determination of topographical radiation dose profiles using gel nanosensors Pushpavanam, Karthik Inamdar, Sahil Dutta, Subhadeep Bista, Tomasz Sokolowski, Thaddeus Boshoven, Eric Sapareto, Stephen Rege, Kaushal Sci Adv Research Articles Despite the emergence of sophisticated technologies in treatment planning and administration, routine determination of delivered radiation doses remains a challenge due to limitations associated with conventional dosimeters. Here, we describe a gel-based nanosensor for the colorimetric detection and quantification of topographical radiation dose profiles in radiotherapy. Exposure to ionizing radiation results in the conversion of gold ions in the gel to gold nanoparticles, which render a visual change in color in the gel due to their plasmonic properties. The intensity of color formed in the gel was used as a quantitative reporter of ionizing radiation. The gel nanosensor was used to detect complex topographical dose patterns including those administered to an anthropomorphic phantom and live canine patients undergoing clinical radiotherapy. The ease of fabrication, operation, rapid readout, colorimetric detection, and relatively low cost illustrate the translational potential of this technology for topographical dose mapping in radiotherapy applications in the clinic. American Association for the Advancement of Science 2019-11-15 /pmc/articles/PMC6858262/ /pubmed/31763446 http://dx.doi.org/10.1126/sciadv.aaw8704 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Pushpavanam, Karthik
Inamdar, Sahil
Dutta, Subhadeep
Bista, Tomasz
Sokolowski, Thaddeus
Boshoven, Eric
Sapareto, Stephen
Rege, Kaushal
Determination of topographical radiation dose profiles using gel nanosensors
title Determination of topographical radiation dose profiles using gel nanosensors
title_full Determination of topographical radiation dose profiles using gel nanosensors
title_fullStr Determination of topographical radiation dose profiles using gel nanosensors
title_full_unstemmed Determination of topographical radiation dose profiles using gel nanosensors
title_short Determination of topographical radiation dose profiles using gel nanosensors
title_sort determination of topographical radiation dose profiles using gel nanosensors
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858262/
https://www.ncbi.nlm.nih.gov/pubmed/31763446
http://dx.doi.org/10.1126/sciadv.aaw8704
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