Structural insights into heme binding to IL-36α proinflammatory cytokine

Cytokines of the interleukin (IL)-1 family regulate immune and inflammatory responses. The recently discovered IL-36 family members are involved in psoriasis, rheumatoid arthritis, and pulmonary diseases. Here, we show that IL-36α interacts with heme thereby contributing to its regulation. Based on...

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Detalles Bibliográficos
Autores principales: Wißbrock, Amelie, Goradia, Nishit B., Kumar, Amit, Paul George, Ajay Abisheck, Kühl, Toni, Bellstedt, Peter, Ramachandran, Ramadurai, Hoffmann, Patrick, Galler, Kerstin, Popp, Jürgen, Neugebauer, Ute, Hampel, Kornelia, Zimmermann, Bastian, Adam, Susanne, Wiendl, Maximilian, Krönke, Gerhard, Hamza, Iqbal, Heinemann, Stefan H., Frey, Silke, Hueber, Axel J., Ohlenschläger, Oliver, Imhof, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858345/
https://www.ncbi.nlm.nih.gov/pubmed/31729440
http://dx.doi.org/10.1038/s41598-019-53231-0

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