A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

N-methyl-D-aspartate receptors (NMDARs), especially GluN2B-containing NMDARs, are associated with neurodegenerative diseases like Parkinson, Alzheimer and Huntington based on their high Ca(2+) conductivity. Overactivation leads to high intracellular Ca(2+) concentrations and cell death rendering Glu...

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Detalles Bibliográficos
Autores principales: Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858350/
https://www.ncbi.nlm.nih.gov/pubmed/31754650
http://dx.doi.org/10.1038/s42003-019-0645-6

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