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mTORC1 activity is essential for erythropoiesis and B cell lineage commitment
Mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that mediates phosphoinositide-3-kinase (PI3K)/AKT signalling. This pathway is involved in a plethora of cellular functions including protein and lipid synthesis, cell migration, cell proliferation and apoptosis. In this stu...
Autores principales: | Malik, Natasha, Dunn, Karen M., Cassels, Jennifer, Hay, Jodie, Estell, Christopher, Sansom, Owen J., Michie, Alison M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858379/ https://www.ncbi.nlm.nih.gov/pubmed/31729420 http://dx.doi.org/10.1038/s41598-019-53141-1 |
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