Role of appetitive phenotype trajectory groups on child body weight during a family-based treatment for children with overweight or obesity

OBJECTIVE: Emerging evidence suggests that individual appetitive traits may usefully explain patterns of weight loss in behavioral weight loss treatments for children. The objective of this study was to identify trajectories of child appetitive traits and the impact on child weight changes over time. METHODS: Secondary data analyses of a randomized noninferiority trial conducted between 2011–2015 evaluated children’s appetitive traits and weight loss. Children with overweight and obesity (mean age=10.4; mean BMIz=2.0; 67% girls; 32% Hispanic) and their parent (mean age=42.9; mean BMI=31.9; 87% women; 31% Hispanic) participated in weight loss programs and completed assessments at baseline, 3-,6-,12- and 24 months. Repeated assessments of child appetitive traits, including satiety responsiveness, food responsiveness and emotional eating were used to identify parsimonious grouping of change trajectories. Linear mixed-effects models were used to identify the impact of group trajectory on child BMIz change over time. RESULTS: One hundred fifty children and their parent enrolled in the study. The 3-group trajectory model was the most parsimonious and included a high satiety responsive group (HighSR; 47.4%), a high food responsive group (HighFR; 34.6%), and a high emotional eating group (HighEE; 18.0%). Children in all trajectories lost weight at approximately the same rate during treatment, however, only the HighSR group maintained their weight loss during follow-ups while the HighFR and HighEE groups regained weight (adjusted p-value <0.05). CONCLUSIONS: Distinct trajectories of child appetitive traits were associated with differential weight loss maintenance. Identified high-risk subgroups may suggest opportunities for targeted intervention and maintenance programs. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: