Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits

The cardiac transcription factor (TF) gene NKX2–5 has been associated with electrocardiographic (EKG) traits through GWAS, but the extent to which differential binding of NKX2–5 at common regulatory variants contributes to these traits has not yet been studied. We analyzed transcriptomic and epigeno...

Descripción completa

Detalles Bibliográficos
Autores principales: Benaglio, Paola, D’Antonio-Chronowska, Agnieszka, Ma, Wubin, Yang, Feng, Young Greenwald, William W., Donovan, Margaret K. R., DeBoever, Christopher, Li, He, Drees, Frauke, Singhal, Sanghamitra, Matsui, Hiroko, van Setten, Jessica, Sotoodehnia, Nona, Gaulton, Kyle J., Smith, Erin N., D’Antonio, Matteo, Rosenfeld, Michael G., Frazer, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858543/
https://www.ncbi.nlm.nih.gov/pubmed/31570892
http://dx.doi.org/10.1038/s41588-019-0499-3

Ejemplares similares

Ejemplares similares