Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity

Immunotherapy has transformed cancer treatment. However, current immunotherapy modalities face various limitations. Here, we developed MAEGI, a new form of immunotherapy that elicits anti-tumor immunity through multiplexed activation of endogenous genes. We leveraged CRISPR activation (CRISPRa) to d...

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Detalles Bibliográficos
Autores principales: Wang, Guangchuan, Chow, Ryan D., Bai, Zhigang, Zhu, Lvyun, Errami, Youssef, Dai, Xiaoyun, Dong, Matthew B., Ye, Lupeng, Zhang, Xiaoya, Renauer, Paul A., Park, Jonathan J., Shen, Li, Ye, Hanghui, Fuchs, Charles S., Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858551/
https://www.ncbi.nlm.nih.gov/pubmed/31611701
http://dx.doi.org/10.1038/s41590-019-0500-4

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