Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination

Self/non-self discrimination is central to T cell-mediated immunity. The kinetic proofreading model can explain T cell antigen receptor (TCR) ligand discrimination; however, the rate-limiting steps have not been identified. Here, we show that tyrosine phosphorylation of the T cell adaptor protein LA...

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Detalles Bibliográficos
Autores principales: Lo, Wan-Lin, Shah, Neel H., Rubin, Sara A., Zhang, Weiguo, Horkova, Veronika, Fallahee, Ian R., Stepanek, Ondrej, Zon, Leonard I., Kuriyan, John, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858552/
https://www.ncbi.nlm.nih.gov/pubmed/31611699
http://dx.doi.org/10.1038/s41590-019-0502-2

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