Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics

We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally-invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery and implantation of invasive fiber-optic cabl...

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Detalles Bibliográficos
Autores principales: Bedbrook, Claire N., Yang, Kevin K., Robinson, J. Elliott, Mackey, Elisha D., Gradinaru, Viviana, Arnold, Frances H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858556/
https://www.ncbi.nlm.nih.gov/pubmed/31611694
http://dx.doi.org/10.1038/s41592-019-0583-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858556/
https://www.ncbi.nlm.nih.gov/pubmed/31611694
http://dx.doi.org/10.1038/s41592-019-0583-8

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