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Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics

We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally-invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery and implantation of invasive fiber-optic cabl...

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Detalles Bibliográficos
Autores principales:	Bedbrook, Claire N., Yang, Kevin K., Robinson, J. Elliott, Mackey, Elisha D., Gradinaru, Viviana, Arnold, Frances H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858556/ https://www.ncbi.nlm.nih.gov/pubmed/31611694 http://dx.doi.org/10.1038/s41592-019-0583-8

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