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Structural basis of temperature sensation by the TRP channel TRPV3
We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergoe α-to-π transitions. Dur...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858569/ https://www.ncbi.nlm.nih.gov/pubmed/31636415 http://dx.doi.org/10.1038/s41594-019-0318-7 |