Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo

Development and differentiation are associated with profound changes to histone modifications, yet their in vivo function remains incompletely understood. Here, we generated mouse models expressing inducible histone H3 lysine-to-methionine mutants, which globally inhibit methylation at specific site...

Descripción completa

Detalles Bibliográficos
Autores principales: Brumbaugh, Justin, Kim, Ik Soo, Ji, Fei, Huebner, Aaron J., Di Stefano, Bruno, Schwarz, Benjamin A., Charlton, Jocelyn, Coffey, Amy, Choi, Jiho, Walsh, Ryan M., Schindler, Jeffery W., Anselmo, Anthony, Meissner, Alexander, Sadreyev, Ruslan I., Bernstein, Bradley, Hock, Hanno, Hochedlinger, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858577/
https://www.ncbi.nlm.nih.gov/pubmed/31659274
http://dx.doi.org/10.1038/s41556-019-0403-5

Ejemplares similares

Ejemplares similares