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Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy

BACKGROUND: The aim of this study was to explore the prognostic factors and establish a nomogram to predict the long-term survival of gastric cancer patients. METHODS: The clinicopathological data of 421 gastric cancer patients, who were treated with radical D2 lymphadenectomy by the same surgical t...

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Autores principales: Mu, Guang-Chuan, Huang, Yuan, Liu, Zhi-Ming, Wu, Xiang-Hua, Qin, Xin-Gan, Chen, Zhi-Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858673/
https://www.ncbi.nlm.nih.gov/pubmed/31729975
http://dx.doi.org/10.1186/s12876-019-1098-6
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author Mu, Guang-Chuan
Huang, Yuan
Liu, Zhi-Ming
Wu, Xiang-Hua
Qin, Xin-Gan
Chen, Zhi-Bai
author_facet Mu, Guang-Chuan
Huang, Yuan
Liu, Zhi-Ming
Wu, Xiang-Hua
Qin, Xin-Gan
Chen, Zhi-Bai
author_sort Mu, Guang-Chuan
collection PubMed
description BACKGROUND: The aim of this study was to explore the prognostic factors and establish a nomogram to predict the long-term survival of gastric cancer patients. METHODS: The clinicopathological data of 421 gastric cancer patients, who were treated with radical D2 lymphadenectomy by the same surgical team between January 2009 and March 2017, were collected. The analysis of long-term survival was performed using Cox regression analysis. Based on the multivariate analysis results, a prognostic nomogram was formulated to predict the 5-year survival rate probability. RESULTS: In the present study, the total overall 3-year and 5-year survival rates were 58.7 and 45.8%, respectively. The results of the univariate Cox regression analysis revealed that tumor staging, tumor location, Borrmann type, the number of lymph nodes dissected, the number of lymph node metastases, positive lymph nodes ratio, lymphocyte count, serum albumin, CEA, CA153, CA199, BMI, tumor size, nerve invasion, and vascular invasion were prognostic factors for gastric cancer (all, P < 0.05). However, merely tumor staging, tumor location, positive lymph node ratio, CA199, BMI, tumor size, nerve invasion, and vascular invasion were independent risk factors, based on the results of the multivariate Cox regression analysis (all, P < 0.05). The nomogram based on eight independent prognostic factors revealed a well-degree of differentiation with a concordance index of 0.76 (95% CI: 0.72–0.79, P < 0.001), which was better than the AJCC-7 staging system (concordance index = 0.68). CONCLUSION: The present study established a nomogram based on eight independent prognostic factors to predict long-term survival in gastric cancer patients. The nomogram would be beneficial for more accurately predicting the prognosis of gastric cancer, and provide important basis for making individualized treatment plans following surgery.
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spelling pubmed-68586732019-11-29 Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy Mu, Guang-Chuan Huang, Yuan Liu, Zhi-Ming Wu, Xiang-Hua Qin, Xin-Gan Chen, Zhi-Bai BMC Gastroenterol Research Article BACKGROUND: The aim of this study was to explore the prognostic factors and establish a nomogram to predict the long-term survival of gastric cancer patients. METHODS: The clinicopathological data of 421 gastric cancer patients, who were treated with radical D2 lymphadenectomy by the same surgical team between January 2009 and March 2017, were collected. The analysis of long-term survival was performed using Cox regression analysis. Based on the multivariate analysis results, a prognostic nomogram was formulated to predict the 5-year survival rate probability. RESULTS: In the present study, the total overall 3-year and 5-year survival rates were 58.7 and 45.8%, respectively. The results of the univariate Cox regression analysis revealed that tumor staging, tumor location, Borrmann type, the number of lymph nodes dissected, the number of lymph node metastases, positive lymph nodes ratio, lymphocyte count, serum albumin, CEA, CA153, CA199, BMI, tumor size, nerve invasion, and vascular invasion were prognostic factors for gastric cancer (all, P < 0.05). However, merely tumor staging, tumor location, positive lymph node ratio, CA199, BMI, tumor size, nerve invasion, and vascular invasion were independent risk factors, based on the results of the multivariate Cox regression analysis (all, P < 0.05). The nomogram based on eight independent prognostic factors revealed a well-degree of differentiation with a concordance index of 0.76 (95% CI: 0.72–0.79, P < 0.001), which was better than the AJCC-7 staging system (concordance index = 0.68). CONCLUSION: The present study established a nomogram based on eight independent prognostic factors to predict long-term survival in gastric cancer patients. The nomogram would be beneficial for more accurately predicting the prognosis of gastric cancer, and provide important basis for making individualized treatment plans following surgery. BioMed Central 2019-11-15 /pmc/articles/PMC6858673/ /pubmed/31729975 http://dx.doi.org/10.1186/s12876-019-1098-6 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Mu, Guang-Chuan
Huang, Yuan
Liu, Zhi-Ming
Wu, Xiang-Hua
Qin, Xin-Gan
Chen, Zhi-Bai
Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
title Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
title_full Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
title_fullStr Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
title_full_unstemmed Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
title_short Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
title_sort application value of nomogram and prognostic factors of gastric cancer patients who underwent d2 radical lymphadenectomy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858673/
https://www.ncbi.nlm.nih.gov/pubmed/31729975
http://dx.doi.org/10.1186/s12876-019-1098-6
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