Rev1 wbdR tagged vaccines against Brucella ovis

Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B....

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Autores principales: Aragón-Aranda, Beatriz, de Miguel, María Jesús, Martínez-Gómez, Estrella, Zúñiga-Ripa, Amaia, Salvador-Bescós, Miriam, Moriyón, Ignacio, Iriarte, Maite, Muñoz, Pilar M., Conde-Álvarez, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858679/
https://www.ncbi.nlm.nih.gov/pubmed/31730501
http://dx.doi.org/10.1186/s13567-019-0714-3
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author Aragón-Aranda, Beatriz
de Miguel, María Jesús
Martínez-Gómez, Estrella
Zúñiga-Ripa, Amaia
Salvador-Bescós, Miriam
Moriyón, Ignacio
Iriarte, Maite
Muñoz, Pilar M.
Conde-Álvarez, Raquel
author_facet Aragón-Aranda, Beatriz
de Miguel, María Jesús
Martínez-Gómez, Estrella
Zúñiga-Ripa, Amaia
Salvador-Bescós, Miriam
Moriyón, Ignacio
Iriarte, Maite
Muñoz, Pilar M.
Conde-Álvarez, Raquel
author_sort Aragón-Aranda, Beatriz
collection PubMed
description Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.
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spelling pubmed-68586792019-11-29 Rev1 wbdR tagged vaccines against Brucella ovis Aragón-Aranda, Beatriz de Miguel, María Jesús Martínez-Gómez, Estrella Zúñiga-Ripa, Amaia Salvador-Bescós, Miriam Moriyón, Ignacio Iriarte, Maite Muñoz, Pilar M. Conde-Álvarez, Raquel Vet Res Research Article Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine. BioMed Central 2019-11-15 2019 /pmc/articles/PMC6858679/ /pubmed/31730501 http://dx.doi.org/10.1186/s13567-019-0714-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Aragón-Aranda, Beatriz
de Miguel, María Jesús
Martínez-Gómez, Estrella
Zúñiga-Ripa, Amaia
Salvador-Bescós, Miriam
Moriyón, Ignacio
Iriarte, Maite
Muñoz, Pilar M.
Conde-Álvarez, Raquel
Rev1 wbdR tagged vaccines against Brucella ovis
title Rev1 wbdR tagged vaccines against Brucella ovis
title_full Rev1 wbdR tagged vaccines against Brucella ovis
title_fullStr Rev1 wbdR tagged vaccines against Brucella ovis
title_full_unstemmed Rev1 wbdR tagged vaccines against Brucella ovis
title_short Rev1 wbdR tagged vaccines against Brucella ovis
title_sort rev1 wbdr tagged vaccines against brucella ovis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858679/
https://www.ncbi.nlm.nih.gov/pubmed/31730501
http://dx.doi.org/10.1186/s13567-019-0714-3
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