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Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea

BACKGROUND: Previous studies reported that stature is inversely related to the risk of cardiovascular disease. However, there is limited evidence on the association between height and lipid profiles. We aimed to examine the association of height with total cholesterol and hypercholesterolemia based...

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Autores principales: Lee, Mi Yeon, Nam, Ga Eun, Han, Kyungdo, Kim, Da Hye, Kim, Yang Hyun, Cho, Kyung Hwan, Park, Yong Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858681/
https://www.ncbi.nlm.nih.gov/pubmed/31729984
http://dx.doi.org/10.1186/s12944-019-1148-7
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author Lee, Mi Yeon
Nam, Ga Eun
Han, Kyungdo
Kim, Da Hye
Kim, Yang Hyun
Cho, Kyung Hwan
Park, Yong Gyu
author_facet Lee, Mi Yeon
Nam, Ga Eun
Han, Kyungdo
Kim, Da Hye
Kim, Yang Hyun
Cho, Kyung Hwan
Park, Yong Gyu
author_sort Lee, Mi Yeon
collection PubMed
description BACKGROUND: Previous studies reported that stature is inversely related to the risk of cardiovascular disease. However, there is limited evidence on the association between height and lipid profiles. We aimed to examine the association of height with total cholesterol and hypercholesterolemia based on the nationally representative dataset of Korean adults. METHODS: The data of 13,701 adults aged ≥19 years who participated in the Korea National Health and Nutrition Examination Survey (2013–2015) were used in this nationwide population-based cross-sectional study. Hypercholesterolemia was defined as a serum total cholesterol level ≥ 240 mg/dL or use of lipid-lowering medications. Multivariable linear regression and logistic regression analyses were used to examine the association of height with mean total cholesterol level and odds ratios (ORs) of hypercholesterolemia. RESULTS: Approximately 17% of participants had hypercholesterolemia. Mean total cholesterol levels decreased in the higher quartile (Q) groups of height after adjusting for confounding variables including age, sex, body mass index, smoking status, alcohol consumption, physical activity, income, educational level, hypertension, and diabetes mellitus (P for trend = 0.035). After adjusting for these potential confounding variables, the adjusted ORs of hypercholesterolemia were significantly lower in the Q3 and Q4 groups than in the Q1 group; ORs decreased in the higher quartile groups of height (OR: 0.83, 95% confidence interval: 0.71–0.99 in Q3; 0.81, 0.69–0.95 in Q4, P for trend = 0.007). The association between height (Q4 vs. Q1–Q3) and hypercholesterolemia was stronger in men or individuals without hypertension or diabetes than in women or individuals with such diseases. CONCLUSIONS: Height is inversely associated with total cholesterol level and odds of hypercholesterolemia among Korean adults. Childhood environment related to short stature may be associated with hypercholesterolemia and cardiovascular health in adulthood.
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spelling pubmed-68586812019-11-29 Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea Lee, Mi Yeon Nam, Ga Eun Han, Kyungdo Kim, Da Hye Kim, Yang Hyun Cho, Kyung Hwan Park, Yong Gyu Lipids Health Dis Research BACKGROUND: Previous studies reported that stature is inversely related to the risk of cardiovascular disease. However, there is limited evidence on the association between height and lipid profiles. We aimed to examine the association of height with total cholesterol and hypercholesterolemia based on the nationally representative dataset of Korean adults. METHODS: The data of 13,701 adults aged ≥19 years who participated in the Korea National Health and Nutrition Examination Survey (2013–2015) were used in this nationwide population-based cross-sectional study. Hypercholesterolemia was defined as a serum total cholesterol level ≥ 240 mg/dL or use of lipid-lowering medications. Multivariable linear regression and logistic regression analyses were used to examine the association of height with mean total cholesterol level and odds ratios (ORs) of hypercholesterolemia. RESULTS: Approximately 17% of participants had hypercholesterolemia. Mean total cholesterol levels decreased in the higher quartile (Q) groups of height after adjusting for confounding variables including age, sex, body mass index, smoking status, alcohol consumption, physical activity, income, educational level, hypertension, and diabetes mellitus (P for trend = 0.035). After adjusting for these potential confounding variables, the adjusted ORs of hypercholesterolemia were significantly lower in the Q3 and Q4 groups than in the Q1 group; ORs decreased in the higher quartile groups of height (OR: 0.83, 95% confidence interval: 0.71–0.99 in Q3; 0.81, 0.69–0.95 in Q4, P for trend = 0.007). The association between height (Q4 vs. Q1–Q3) and hypercholesterolemia was stronger in men or individuals without hypertension or diabetes than in women or individuals with such diseases. CONCLUSIONS: Height is inversely associated with total cholesterol level and odds of hypercholesterolemia among Korean adults. Childhood environment related to short stature may be associated with hypercholesterolemia and cardiovascular health in adulthood. BioMed Central 2019-11-15 /pmc/articles/PMC6858681/ /pubmed/31729984 http://dx.doi.org/10.1186/s12944-019-1148-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Lee, Mi Yeon
Nam, Ga Eun
Han, Kyungdo
Kim, Da Hye
Kim, Yang Hyun
Cho, Kyung Hwan
Park, Yong Gyu
Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea
title Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea
title_full Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea
title_fullStr Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea
title_full_unstemmed Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea
title_short Association between height and hypercholesterolemia in adults: a nationwide population-based study in Korea
title_sort association between height and hypercholesterolemia in adults: a nationwide population-based study in korea
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858681/
https://www.ncbi.nlm.nih.gov/pubmed/31729984
http://dx.doi.org/10.1186/s12944-019-1148-7
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