Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene

BACKGROUND: Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transport. Among these, SCN1A encodes the voltage-gated Na(+) channel Nav1.1, and FHM c...

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Detalles Bibliográficos
Autores principales: Barbieri, R., Bertelli, S., Pusch, M., Gavazzo, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858687/
https://www.ncbi.nlm.nih.gov/pubmed/31730442
http://dx.doi.org/10.1186/s10194-019-1056-2

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