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Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke

BACKGROUND: Endothelin-1 (ET-1) is synthesized and upregulated in astrocytes under stroke. We previously demonstrated that transgenic mice over-expressing astrocytic ET-1 (GET-1) displayed more severe neurological deficits characterized by a larger infarct after transient middle cerebral artery occl...

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Detalles Bibliográficos
Autores principales:	Cheng, Xiao, Yeung, Patrick K. K., Zhong, Ke, Zilundu, Prince L. M., Zhou, Lihua, Chung, Sookja K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858703/ https://www.ncbi.nlm.nih.gov/pubmed/31733648 http://dx.doi.org/10.1186/s12974-019-1597-y

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