The density and spatial tissue distribution of CD8(+) and CD163(+) immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

BACKGROUND: Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to treatment clinical benefit, the pre-existing level of immunity at tumor site may provide biomarkers of disease o...

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Detalles Bibliográficos
Autores principales: Massi, Daniela, Rulli, Eliana, Cossa, Mara, Valeri, Barbara, Rodolfo, Monica, Merelli, Barbara, De Logu, Francesco, Nassini, Romina, Del Vecchio, Michele, Di Guardo, Lorenza, De Penni, Roberta, Guida, Michele, Sileni, Vanna Chiarion, Di Giacomo, Anna Maria, Tucci, Marco, Occelli, Marcella, Portelli, Francesca, Vallacchi, Viviana, Consoli, Francesca, Quaglino, Pietro, Queirolo, Paola, Baroni, Gianna, Carnevale-Schianca, Fabrizio, Cattaneo, Laura, Minisini, Alessandro, Palmieri, Giuseppe, Rivoltini, Licia, Mandalà, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858711/
https://www.ncbi.nlm.nih.gov/pubmed/31730502
http://dx.doi.org/10.1186/s40425-019-0797-4

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